About 31 results found for searched term "Melanocortin Receptor" (0.123 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M31361 | Recombinant Human MRAP Protein (HEK293, hFc Tag) | Recombinant Proteins |
| Melanocortin 2 Receptor Accessory Protein; FALP; B27 | ||
| MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. A DNA sequence encoding the human MRAP (Tyr59-Ser172) was expressed with the Fc region of human IgG1 at the N-terminus. | ||
| M10063 | Bremelanotide Acetate | Melanocortin Receptor |
| PT-141 Acetate | ||
| Bremelanotide Acetate (PT-141 Acetate) is a peptide containing seven amino acids and is also a macrocyclic compound. In addition, Bremelanotide Acetate is an agonist of the melanocortin 4 receptor (MC4R). | ||
| M10201 | Seractide; ACTH (1-39), human | Peptides |
| Adrenocorticotropic Hormone (1-39) | ||
| Seractide; ACTH (1-39), human is a member of the melanocortin family, stimulates production of CS by the adrenals, acts as a melanocortin receptor agonist. | ||
| M10206 | ACTH (1-39), rat | Peptides |
| Adrenocorticotropic Hormone (1-39), rat | ||
| ACTH (1-39), rat is a potent melanocortin 2 (MC2) receptor agonist. | ||
| M10677 | β-Melanocyte Stimulating Hormone TFA, human | Melanocortin Receptor |
| β-MSH | ||
| β-Melanocyte Stimulating Hormone TFA, human is a 22-residue peptide, which acts as an endogenous melanocortin-4 receptor (MC4-R) agonist. | ||
| M11364 | α-MSH TFA | Melanocortin Receptor |
| alpha-MSH Trifluoroacetate; α-Melanocyte-stimulating hormone TFA, | ||
| As an endogenous neuropeptide, alpha-melanocyte-stimulating hormone (TFA) is an endogenous melanocortin receptor 4 (MC4R) agonist with anti-inflammatory and antipyretic effects. α-MSH TFA is a posttranslational derivative of preopelanocorticoid (POMC). | ||
| M14010 | THIQ | Melanocortin Receptor |
| THIQ is the first selective agonist of the melanocortin-4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1.2 nM, EC50=2.1 nM) and rMC4R (IC50=0.6 nM, EC50=2.9 nM). | ||
| M27738 | SNT-207707 | Melanocortin Receptor |
| SNT-207707 is a selective, potent and orally active melanocortin MC-4 receptor antagonist with an IC50 of 8 nM (binding) and 5 nM (function) on the MC-4 receptor. | ||
| M27798 | SNT-207858 | Melanocortin Receptor |
| SNT207858 is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor. | ||
| M27800 | SNT-207858 free base | Melanocortin Receptor |
| SNT207858 free base is a selective, blood brain barrier penetrating, potent and orally active melanocortin-4 (MC-4) receptor antagonist. SNT207858 free base has an IC50 of 22 nM (binding) and 11 nM (function) on the MC-4 receptor. | ||
| M27951 | Melanotan (MT)-II | Peptides |
| (MT)-II | ||
| Melanotan (MT)-II, a synthetic melanocortin receptor agonist, is an injectable peptide hormone used to promote tanning. | ||
| M28807 | SHU 9119 acetate | Melanocortin Receptor |
| SHU 9119 acetate is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively. | ||
| M28821 | ML-00253764 hydrochloride | Melanocortin Receptor |
| ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 µM and 0.103 µM, respectively. | ||
| M30113 | MK-0493 | Melanocortin Receptor |
| MK-0493 is a potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R), demonstrating significant reductions in energy intake. | ||
| M30454 | PG-931 | Melanocortin Receptor |
| PG-931, an analog of SHU 9119, is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R (IC50=2.4 nM). PG-931 can reverse haemorrhagic shock and prevent multiple organ damage in vivo. | ||
| M30476 | ML00253764 | Melanocortin Receptor |
| ML00253764 is a selective melanocortin receptor 4 (MC4R) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity. | ||
| M31034 | PG-931 TFA | Melanocortin Receptor |
| PG-931 TFA, an analog of SHU 9119, is a potent melanocortin 4 (MC4) receptor (IC50=0.58 nM) agonist and is more selective than for the hMC3R (IC50=55 nM) or the hMC5R(IC50=2.4 nM). PG-931 TFA can reverse haemorrhagic shock and prevent multiple organ damage in vivo. | ||
| M31337 | PL-8331 | Melanocortin Receptor |
| PL-8331 is a synthetic peptide that is also an agonist of the melanocortin receptors MC1R and MC5R and can be used in diabetes-related studies. | ||
| M40531 | LB54640 | Melanocortin Receptor |
| LB54640 is a melanocortin receptor-4 (MC4R) antagonist that may be used in studies of obesity associated with POMC deficiency. | ||
| M41869 | Resomelagon acetate | Melanocortin Receptor |
| Resomelagon (AP1189) acetate is a potent, orally active melanocortin receptor (MR) agonist about MC1 and MC3. | ||
| M43965 | RO27-3225 TFA | Melanocortin Receptor |
| RO273225 TFA | ||
| RO27-3225 TFA is a potent, selective melanocortin type 4 receptor (MC4R) agonist with EC50s of 1 nM for MC4R and 8 nM for MC1R, with neuroprotective and anti-inflammatory activity, which attenuates gut dysfunction and brain damage. | ||
| M49831 | Melanotan I | Melanocortin Receptor |
| Afamelanotide; MT-I; [Nle4,D-Phe7]-α-MSH | ||
| Melanotan I is a synthetic analog of α-Melanocyte Stimulating Hormone (α-MSH) and a potent non-selective melanocortin receptor (MCR) agonist that stimulates melanogenesis Melanotan I can be used in studies related to sunlight-induced skin cancer. | ||
| M50223 | Org-2766 | Melanocortin Receptor |
| Org-2766 is an analog and neurotrophic peptide of the adrenocorticotropic hormone ACTH (4-9) fragment and a melanocortin receptor 2 (MC2R) agonist.Org-2766 can be used in studies related to aging. | ||
| M53077 | PG106 | Melanocortin Receptor |
| PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor. | ||
| M53079 | HS014 | Melanocortin Receptor |
| HS014 is a potent and selective melanocortin-4 (MC4) receptor antagonist, with Kis of 3.16, 108, 54.4 and 694 nM for human MC4, MC1, MC3 and MC5 receptors, respectively. | ||
| M53080 | TCMCB07 | Melanocortin Receptor |
| TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. | ||
| M53081 | MCL0020 | Melanocortin Receptor |
| MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC50 of 11.63 nM. | ||
| M53090 | β-Melanocyte Stimulating Hormone (MSH), human | Melanocortin Receptor |
| β-Melanocyte Stimulating Hormone (MSH), human, a 22-residue peptide, acts as an endogenous melanocortin-4 receptor (MC4-R) agonist. | ||
| M53094 | ACTH (1-17) | Melanocortin Receptor |
| ACTH (1-17), an adrenocorticotropin analogue, is a potent human melanocortin 1 (MC1) receptor agonist with a Ki of 0.21 nM. | ||
| M53868 | SHU 9119 | Melanocortin Receptor |
| SHU 9119 is a potent human melanocortin 3 and 4 receptors (MC3/4R) antagonist and a partial MC5R agonist; with IC50 values of 0.23, 0.06, and 0.09 nM for human MC3R, MC4R and MC5R, respectively. | ||
| M53869 | [D-Trp8]-γ-MSH | Melanocortin Receptor |
| [D-Trp8]-γ-MSH is a potent and selective agonist of melanocortin 3 (MC3) receptor, with IC50s of 6.7 nM, 600 nM and 340 nM for hMC3, hMC4 and hMC5, respectively in CHO cells. | ||
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